Investigating environmental links to disease
Our ground-breaking, multidisciplinary research answers important questions on how chemicals and contaminants in our homes and environment affect fertility, pregnancy, fetal and child development, and health equity. We prioritize filling gaps in knowledge that support clinical decision-making and public policy.
We have written or contributed to more than 180 studies on health and the environment with 23 studies published in peer-reviewed journals in 2020 alone.
UCSF Study Finds Evidence of 55 Chemicals Never Before Reported in People
Scientists at UC San Francisco have detected 109 chemicals in a study of pregnant women, including 55 chemicals never before reported in people and 42 “mystery chemicals,” whose sources and uses are unknown. The chemicals most likely come from consumer products or other industrial sources.
The study was published March 17 in Environmental Science & Technology.
Major Research Areas
Chemicals
We study how harmful chemicals put into our air, food, water, homes, products, and workplaces affect pregnancy, child development, and health.
Plastics
Plastics are a petro-chemical product packed with endocrine-disrupting chemicals that can harm pregnancy, birth outcomes, neurodevelopment, and immune systems.
Climate
We examine how climate is impacting women's and children's health, pregnancy, people of color, and fenceline communities
Key Research Projects
ECHO
The Environmental Influences on Child Health Outcomes (ECHO) is the largest NIH-funded study to date to explore how chemicals and pollutants in our environment impact pregnancy and child development.
DREAM
The Discovering cancer Risks from Environmental contaminants And Maternal/child health (DREAM) project collected data to explore how chemicals put in our air, food, and water increase cancer risk.
ENACT Center
In partnership with Stanford University, the Endometriosis Center for Action, Community Engagement and Training (ENACT) will work to improve endometriosis diagnosis and treatment by exploring the origins and environmental links to this disease.
Published Studies
Pollution, including air pollution, water pollution, pollution from lead and other chemicals, and toxic occupational exposures, is the leading cause of premature death globally, with more than 90% of pollution-related deaths occurring in low- and middle-income countries. Chemical pollution is estimated to be responsible for at least 1.8 million deaths each year. This number is probably an underestimate, since less than 5% of approximately 350,000 chemicals registered for use globally have been adequately studied; most countries do not require testing for chemical health harms or disclosure of use.
Some hormonally active cancers have low survival rates, but a large proportion of their incidence remains unexplained. Endocrine disrupting chemicals may affect hormone pathways in the pathology of these cancers.
We identified both exogenous and endogenous chemicals seldom quantified in pregnant study participants that were also related to pregnancy complications and demonstrated the utility of NTA to identify chemical exposures of concern.
Despite the occurrence of wildfires quadrupling over the past four decades, the health effects associated with wildfire smoke exposures during pregnancy remains unknown. Our study of 7923 singleton births in San Francisco between January 1, 2017 and March 12, 2020 examines associations between wildfire smoke exposure during pregnancy and birthweight.
Climate change is accelerating the intensity and frequency of wildfires globally. Understanding how wildfire smoke (WS) may lead to adverse pregnancy outcomes and alterations in placental function via biological mechanisms is critical to mitigate the harms of exposure.
Despite their large numbers and widespread use, very little is known about the extent to which per- and polyfluoroalkyl substances (PFAS) can cross the placenta and expose the developing fetus.
Oxidative stress from excess reactive oxygen species (ROS) is a hypothesized contributor to preterm birth. Per- and polyfluoroalkyl substances (PFAS) exposure is reported to generate ROS in laboratory settings, and is linked to adverse birth outcomes globally. However, to our knowledge, the relationship between PFAS and oxidative stress has not been examined in the context of human pregnancy.