Turning Science into Action
People are exposed to increasing amounts of toxic chemicals in air, food, water, personal care and cleaning products, at home and at work. The problem is so large, we cannot protect ourselves with individual actions alone - we need policy change.
That's why we share the science and best scientific methods to inform and guide policies that protect people from harmful chemicals, particularly those who are especially vulnerable such as pregnant people and children, and those who are disproportionately impacted.
How to Strengthen EPA's Mission to Protect Health
To help EPA put science and public health front and center, PRHE collaborated with top scientists and chemical policy experts from around the country to develop evidence-based recommendations to improve hazard and risk assessment, and prevent harms from chemicals and pollutants.
Major Policy Areas
Chemicals and TSCA
We analyze federal chemical policy and EPA's implementation of the updated Toxic Substances Control Act, the law that governs regulations of chemicals in commerce.
Science Integrity
PRHE developed the Navigation Guide systematic review methodology to better evaluate the quality and strength of the evidence on how hazardous chemicals impact health.
Industry Documents
From lead and tobacco to hiding the truth about fossil fuels and climate, polluters have a long history of manipulating science and public opinion to maintain their corporate interests. We help gather these documents as part of UCSF's Industry Documents Library.
Policy Strategies
Public Comments
We monitor EPA and other regulatory body actions and comment on whether they are following the best science and protecting health. Public comments are essential to holding government agencies accountable.
Legislative Briefings
PRHE planned legislative briefings to inform policymakers and staff about issues related to implementation of the Toxic Substances Control Act and science and decision making at EPA.
Science Action Network
PRHE launched the Science Action Network for Health and the Environment to bring together environmental health scientists to be a strong voice for science integrity and to prioritize health in chemical and environmental policy.
Published Papers
Systematic review (SR) is a rigorous, protocol-driven approach designed to minimise error and bias when summarising the body of research evidence relevant to a specific scientific question. Taking as a comparator the use of SR in synthesising research in healthcare, we argue that SR methods could also pave the way for a “step change” in the transparency, objectivity and communication of chemical risk assessments (CRA) in Europe and elsewhere.
The health impact of exposure to environmental chemicals can be an elusive and difficult concept to grasp. We lack complete data and understanding on the extent to which the industrial chemicals present in our everyday lives—in our food, water, air, and the products we use every day—impact our health.
Glomerular filtration rate (GFR) may influence concentrations of biomarkers of exposure and their etiologic significance in observational studies of associations between environmental contaminants and fetal growth. It is unknown whether the size of a developing fetus affects maternal GFR such that a small fetus leads to reduced plasma volume expansion (PVE), reduced GFR and subsequent higher concentrations of biomarkers in maternal serum.
The Navigation Guide is a novel systematic review method to synthesize scientific evidence and reach strength of evidence conclusions for environmental health decision making. Our aim was to integrate scientific findings from human and nonhuman studies to determine the overall strength of evidence for the question “Does developmental exposure to perfluorooctanoic acid (PFOA) affect fetal growth in humans?”
Synthesizing what is known about the environmental drivers of health is instrumental to taking prevention-oriented action. Methods of research synthesis commonly used in environmental health lag behind systematic review methods developed in the clinical sciences over the past 20 years.
The size and molecular configuration of nanoparticles yield unique properties that are being explored for use in commercial products, medicine and environmental cleanup, but the hazards they present to fertility and reproduction, as well as overall health, are unknown. As part of an effort to anticipate emerging exposures of concern to fertility and reproduction, PRHE developed a policy framework for the Office of Environmental Health Hazard Assessment of the California Environmental Protection Agency.